Yale researchers have conducted an experiment on “humanized mice” to try and get insight into why some people experience more severe symptoms than others when contracting the COVID-19 virus. The study found a link between the body’s inflammatory response to infection.
Researchers also found two well-known therapies, monoclonal antibodies and the steroid dexamethasone, can help treat COVID-19. The study was conducted on mice who were “engineered to possess human-like immune systems” states the Yale report published in the journal Nature Biotechnology. Researchers posed the question, “why do 80 to 90% of people infected with COVID-19 experience only mild cases while 10 to 20% face more severe or life-threatening symptoms?”
Thus far comparing the virus in humans and laboratory animals “made it difficult for scientists to pinpoint the tipping point between mild and severe cases of COVID-19.” But, the unique use of rodents with humanized immune systems offered this finding to researchers:
“If you infect a standard laboratory mouse with SARS-CoV-2 they will get infected, but not get seriously ill,” said Flavell, Sterling Professor of Immunobiology at Yale and senior author of the paper. “But our humanized mice get sick and just don’t get better. Their whole immune system is on fire.”
The research team — which was led by first author Esen Sefik, a Howard Hughes Medical Institute (HHMI) Fellow at the Damon Runyon Cancer Research Foundation — introduced SARS-CoV-2 virus taken from seriously ill human patients into the nasal passages of their humanized mice and then followed the course of the disease.
They found that the infected mice exhibited the same symptoms as severely ill human patients, such as lung damage, weight loss, and a heightened, persistent inflammatory immune response that damages tissues. They then treated the mice with monoclonal antibodies provided by Michel Nussenzweig, an immunologist at Rockefeller University and, like Flavell, an HHMI investigator. These antibodies, which specifically target the virus, were effective if given before or very early after infection but did little to stifle symptoms if administered in later stages of infections, they found.
Conversely, during the early stages of infection the immune suppressant dexamethasone was fatal to mice when it suppressed the initial immune response that was crucial to combat the virus. However, it helped clear infection during later stages of disease by suppressing the inflammatory response that had begun damaging organs.
“Early in the course of the disease, a strong immune response is crucial for survival,” Sefik said. “Later in the disease, it can be fatal.”
You may like
CIA whistleblower: analysts given money to bury covid lab-leak theory
The House Select Subcommittee on the Coronavirus Pandemic sent a letter to CIA director William Burns discussing the CIA and a COVID-19 cover-up. The letter asserts that it has knowledge from a whistleblower from the CIA’s “Covid Discovery Team” that was tasked with investigating the origins of the novel coronavirus. “New testimony from a highly credibly whistleblower” alleges that the CIA “rewarded six analysts with significant financial incentives to change their COVID-19 origins conclusion from a lab-leak to zoonosis
Apart from a “lone officer” in the group who believed the virus “originated through zoonosis,” the remaining officials agreed that, on balance of probabilities, the coronavirus was likely the result of a lab-leak.
“According to the whistleblower, at the end of its review, six of the seven members of the Team believed the intelligence and science were sufficient to make a low confidence assessment that Covid-19 originated from a laboratory in Wuhan, China,” the letter reads. “To come to the eventual public determination of uncertainty, the other six members were given a significant monetary incentive to change their position.”
In June, the agency declassified its report that the available evidence on the origins of the coronavirus suggested it “was not genetically engineered.”
New testimony from a highly credible whistleblower alleges @CIA rewarded six analysts with significant financial incentives to change their COVID-19 origins conclusion from a lab-leak to zoonosis. pic.twitter.com/KIemfi2Wgl
— Select Subcommittee on the Coronavirus Pandemic (@COVIDSelect) September 12, 2023
You may like
War on Drugs6 days ago
Kilo of fentanyl found on children’s mats at Bronx daycare, 4 children overdosed, 1 year old boy dies
War on Drugs7 days ago
Children under 14 dying from fentanyl poisoning at ‘faster rate than any other age group’
Elections6 days ago
Eric Clapton Raises $2.2 Million for Robert F. Kennedy, Jr.’s Presidential Campaign
Podcast5 days ago
Sara’s Urgent Message: We Have A Country to Save & We Can’t Save It Without Your Help