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Study Using Mice with ‘Humanized Immune Systems’ Help Suggest why COVID-19 Makes some Sicker than Others

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Yale researchers have conducted an experiment on “humanized mice” to try and get insight into why some people experience more severe symptoms than others when contracting the COVID-19 virus. The study found a link between the body’s inflammatory response to infection.

Researchers also found two well-known therapies, monoclonal antibodies and the steroid dexamethasone, can help treat COVID-19. The study was conducted on mice who were “engineered to possess human-like immune systems” states the Yale report published in the journal Nature Biotechnology. Researchers posed the question, “why do 80 to 90% of people infected with COVID-19 experience only mild cases while 10 to 20% face more severe or life-threatening symptoms?”

Thus far comparing the virus in humans and laboratory animals “made it difficult for scientists to pinpoint the tipping point between mild and severe cases of COVID-19.” But, the unique use of rodents with humanized immune systems offered this finding to researchers:

“If you infect a standard laboratory mouse with SARS-CoV-2 they will get infected, but not get seriously ill,” said Flavell, Sterling Professor of Immunobiology at Yale and senior author of the paper. “But our humanized mice get sick and just don’t get better. Their whole immune system is on fire.”

The research team — which was led by first author Esen Sefik, a Howard Hughes Medical Institute (HHMI) Fellow at the Damon Runyon Cancer Research Foundation — introduced SARS-CoV-2 virus taken from seriously ill human patients into the nasal passages of their humanized mice and then followed the course of the disease.

They found that the infected mice exhibited the same symptoms as severely ill human patients, such as lung damage, weight loss, and a heightened, persistent inflammatory immune response that damages tissues. They then treated the mice with monoclonal antibodies provided by Michel Nussenzweig, an immunologist at Rockefeller University and, like Flavell, an HHMI investigator. These antibodies, which specifically target the virus, were effective if given before or very early after infection but did little to stifle symptoms if administered in later stages of infections, they found.

Conversely, during the early stages of infection the immune suppressant dexamethasone was fatal to mice when it suppressed the initial immune response that was crucial to combat the virus. However, it helped clear infection during later stages of disease by suppressing the inflammatory response that had begun damaging organs.

“Early in the course of the disease, a strong immune response is crucial for survival,” Sefik said. “Later in the disease, it can be fatal.”

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5 Comments

5 Comments

  1. Todd Rogers

    December 28, 2021 at 5:55 pm

    My gosh Sara! Thank you for all your hard work and investigation skills!
    I can’t believe how much these Covid lies are making people just go right along with this! Ugh!

  2. nate

    December 28, 2021 at 6:22 pm

    A perfect lab developed virus. Makes you wonder, if only the fittest are to survive? Recover social security from those deceased, lesson the burden on hospitals due to the weak? Adolph Hitler had a plan to eradicate the weak for the strong, his strong, The Third Reich strong! Is a point in history repeating itself? History has repeated itself when lessons are NOT LEARNED! It was military, dictatorship, government control then?, What would you call it today? Government does like to control? Socialism is control.

  3. schutzhund

    December 29, 2021 at 8:26 am

    What about “pre-disposition” and “pre-existing”?
    When will this be looked at before the disease is introduced?

  4. dfmd

    December 29, 2021 at 1:28 pm

    Lab rats are not given a history and physical examination. First they don’t speak English and secondly did you ever try to draw blood from a lab rat? Are you a mouse whisperer?

  5. JusSayin

    January 2, 2022 at 2:21 pm

    Sadly, the mice are humanized using livers and thymus from living, pre-aborted, preferably female, humans with a gestational age ranging from 6 to 42 weeks according to the FDA’s contract

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COVID-19

Biden: ‘We Need More Money to Plan for the Second Pandemic’

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Screen Shot 2021 09 22 at 10.47.01 AM

There’s nothing more reassuring than a President telling Americans that no matter how much they are suffering, more is coming.

Biden was asked the question “how many of the nation’s kids will you be able to get vaccinated before you need more money from Congress?”

“We’ll get through at least this year. We, we do need more money. But we don’t just need more money for vaccines for children eventually…”

And then Biden said this harrowing statement: “We need more money to plan for the second pandemic.”

He then emphasizes, “there’s going to be another pandemic. We have to think ahead. And that’s not something the last outfit did very well; that’s something we’ve been doing fairly well” he adds before concluding, “that’s why we need the money.”

 

 

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