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Ebola Drug Remdesivir Shows Early Signs Of Hope In Treating COVID Patients

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A drug used to treat Ebola patients, Redesivir, is showing signs of hope against the COVID-19 virus in early trials, according to a press release from biopharmaceutical company Gilead Sciences.

The drug is also used for Marburg, MERS and SARS viruses.

“Unlike traditional drug development, we are attempting to evaluate an investigational agent alongside an evolving global pandemic. Multiple concurrent studies are helping inform whether remdesivir is a safe and effective treatment for COVID-19 and how to best utilize the drug,” said Merdad Parsey, MD, PhD, Chief Medical Officer, Gilead Sciences in a statement released Wednesday.

The statement continued, “These study results complement data from the placebo-controlled study of remdesivir conducted by the National Institute for Allergy and Infectious Diseases and help to determine the optimal duration of treatment with remdesivir. The study demonstrates the potential for some patients to be treated with a 5-day regimen, which could significantly expand the number of patients who could be treated with our current supply of remdesivir. This is particularly important in the setting of a pandemic, to help hospitals and healthcare workers treat more patients in urgent need of care.”

The trial found that patients who received a 5-day dosage of the medication showed similar signs of improvement compared to a 10-day dosage. More than half of the patients treated early on in their diagnosis were discharged from the hospital before 14 days, according to the release.

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Healthcare

NY Gov Hochul issues executive order: Polio ‘an official diisaster’

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New York Democrat Governor Kathy Hochul on Friday issued an executive order that Polio is now considered an official disaster. 

“On polio, we simply cannot roll the dice,” said Dr. Mary T. Bassett, New York State Health Commissioner. “If you or your child are unvaccinated or not up-to-date with vaccinations, the risk of paralytic disease is real. I urge New Yorkers to not accept any risk at all.”

The virus that causes polio has been found in the wastewater of more than one county, according to state health officials. “A sewage sample from Nassau County collected in August tested positive for poliovirus, following the prior detection of the virus in wastewater samples in Rockland County, Orange County, Sullivan County and New York City, further indicating that the virus is spreading in the area to some degree” reports The Wall Street Journal.

“The Nassau County sample was also genetically linked to the single confirmed case of paralytic polio that had been identified this summer in a young adult resident in Rockland County who was unvaccinated.”

Hochul’s executive order has been issued through Oct. 9, and expands the network of providers able to administer polio vaccinations to “include emergency-medical-services workers, midwives and pharmacists.”

The new order makes providers send polio-immunization data to the New York State Department of Health in order to better help health officials “focus vaccination efforts on areas of low uptake.”

New York state health officials have sent out alerts to providers, have hung fliers “in houses of worship, grocery stores and summer camps and talked with community leaders about boosting vaccination rates this summer.”

The Wall Street Journal Reports:

The poliovirus spreads mostly when a person touches their mouth after coming in contact with an infected person’s feces. Most infected people don’t develop any symptoms but can still spread the virus, a major concern for health officials, and around a quarter develop flulike symptoms. Those who are vaccinated are at low risk, health officials have said, as getting three doses of the polio vaccine administered in the U.S. is at least 99% effective at preventing paralytic disease.

Health officials, however, also said that certain New Yorkers who are fully vaccinated but at high-risk should receive a single lifetime booster. That applies to individuals who will or might have close contact with a suspected or confirmed polio patient, as well as healthcare workers in those areas who might handle poliovirus samples or treat patients who might have polio…

Two forms of the virus can cause paralysis, one of them being the wild poliovirus found in nature. The case in New York, on the other hand, is caused by vaccine-derived poliovirus, a mutated form of a strain used in an oral polio vaccine…

The oral polio vaccine, used in many parts of the world outside of the U.S., relies on a weakened, live form of the virus that recently inoculated children shed in their feces. In places with lower vaccine uptake, the weakened virus can sometimes circulate and mutate to become more like the wild virus and potentially paralyze people who are not fully vaccinated.

 

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